Antibodies for Licensing

Antibodies for Licensing Scientists at the Georg-August-University Göttingen generated many different monoclonal antibodies. We are looking for companies, who are interested in licensing these antibodies for selling them to industrial and scientific institutions or for developing advanced diagnostic tests and therapeutic solutions. This unique collection comprises the listed clones:

Overview available clones for licensing page 1

Name

Clones

Host

Reactivity

Isotype

Application

References

Complementfactor B / Ba

P21/15

mouse

human

IgG2a/k

WB,E,IP

1-3

M20/6

mouse

human

IgG1/k

WB,E,IP

1-4

D22/3

mouse

human

IgG2b/k

WB,F,E

2-4

Complementfactor B / Bb

M13/12

mouse

human

IgG1/k

WB,E,IP

1-3

Complementfactor D

D10/4

mouse

human

IgG2a/k

WB,E

1-3; 5

I8/1

mouse

human

IgG1/k

WB,E

1-3; 5

Complementfactor H

C18/3

mouse

human

IgG1/k

WB,E

1-3

L20/3

mouse

human

Ig1/k

WB,E

1-3

Complementfactor H (402-His variant)

23F8

mouse

human

lgG1/k

IB, ELISA

not yet published

Complementfactor H (402-Tyr variant)

1H10

mouse

human

lgG1/k

IB, ELISA

not yet published

Activated C3 (iC3b/C3dg)

I3/15

mouse

human

Ig1/k

WB,E

1-3; 6; 7

C3a/C3a(desArg)/C3

K13/16

mouse

human

IgG1/k

WB,E,IP,FN

2; 3; 8-16

D17/1

mouse

human

IgG1/k

WB,E

2; 3; 8; 10; 14-16

C5a/C5a(desArg)/C5

C17/5

mouse

human

IgG1/k

WB,E

2; 3; 8; 10: 14-16; 19

G25/2

mouse

human

IgG1/k

WB,E

2; 3; 8; 10: 14-16; 19

Overview available clones for licensing page 2

Name

Clones

Host

Reactivity

Isotype

Application

References

C3a/C3a(desArg)

Z22/8

mouse

porcine

IgG2b/k

WB,E,IP,FN

3; 17;18

K5/9

mouse

porcine

IgG1/k

WB, E,FN

3; 17;18

C5a/C5a (desArg)

T13/9

mouse

porcine

IgG1/k

WB,E,IP,FN

3; 17;18

Complementreceptor C5aR (CD88)

P12/1

mouse

human

IgG1/k

WB, F, IH

S5/1

mouse

human

IgG2a/k

WB, F, E, FN, IP, blocking

W17/1

mouse

human

IgG1/k

F,E

R63

mouse

rat

IgG1/k

F,IH

Phospho-C5aR/CD88 (Ser-334)

32G-1

mouse

human

IgG1/k

WB, IF, E20

Chemokine receptor CCR5

R22/7

mouse

human

IF, FC, WB

T21/8

mouse

human

IgG2a/k

IF, FC, WB, IP, E

Phospho CCR5 (Ser-349)

E11/19

mouse

human

IF, WB, E

Phospho CCR5 (Ser-337)

V14/2

mouse

human

I, WB, E

Nonphospho-CCR5 (Ser 337)

RC-10

mouse

human

IF, WB, E

R22/7

mouse

human

IF, FC,WB

Chemokine receptor CCR7

4B12

rat

mouse

IgG2a

IP, F

23; 24

Nonphospho-CCR5 (Ser 337)

hC3aRZ8 (clone17)

mouse

human

IgG2b

F, IH

25; 26

hC3aRZ3 (clone76)

mouse

human

IgG2b

27;28

Overview available clones for licensing page 3

Name

Clones

Host

Reactivity

Isotype

Application

References

mouse

rat

F, IH

IG4

rat

mouse

IgG1/k

F, IH

14D4

rat

mouse

IgG2a

F, IH

Complementreceptor C5aR

20/70

rat

mouse

IgG2b

F, Blocking

30;31;32

10/92

rat

mouse

IgG2a

F, IH

8D6

rat

human

IgG2a

F, IH, Blocking

not yet published

15C4

rat

human

IgG2a

F, IH, Blocking

not yet published

Beta-arrestin1 and Beta-arrestin2

25G10

mouse

human, rat,hamster beta-arrestin1

IgG1/k

WB, IP

not yet published

21B1

mouse

human, rat,hamster beta-arrestin1

Ig1/k

WB, IP

Chemokine receptor CCR9

9B1

rat

mouse

IgG2a/k

Interleukin 8

SE2

mouse

human

IgG2b/k

F, WB, IH

HC2

mouse

human

IgG1/k

F, WB, IH

Complementfactor H

IH10

mouse

human

IgG1/k

IB, ELISA

not yet published

23F8

mouse

human

IgG1/k

IB, ELISA

not yet published

Beta2-adrenergic receptor

13D6

mouse

human

IgG1/k

IB, IP, IF, F

not yet published

R11E1

mouse

human

IgG1/k

IB, IP, IF, F

Overview available clones for licensing page 4

Name

Clones

Host

Reactivity

Isotype

Application

References

PIWIL2

87/3

mouse

human

lgM

IH, ELISA

not yet published

Pox Viruses

BCoV1/1

mouse

bovine coronavirus; human coronavirus

lgG1

E; IF; VN

FPXV-8F3

mouse

Fowlpoxvirus, Turkeypoxvirus

IgG3/k

E, IF, IB, IP, IGEM, NVN

FPXV-3D9

mouse

Fowlpoxvirus, Turkeypoxvirus

IgG1

E, IF, IB, IP, IGEM, NVN

36;37

VACV-5B4

mouse

All orthopoxviruses without ectomelia and monkeypox

IgG2a

E, IF, IB, IP, F, IGEM, VN

38;39;40

VACV-5C7

mouse

Monkeypoyvirus and other orthopoxviruses

IgG1

E, IF, IB, IP, IGEM, NVN

PPV-4D9

mouse

All Parapoxviruses

IgM

E, IF, IB, IP, F, IGEM, VN

CNPV-5A11

mouse

Canarypox virus

IgG2a/k

E, IF, IB, IP, IGEM, NVN

VACV-5B1

mouse

All orthopoxviruses

IgG2a

E, IF, IB, IP, F, IGEM, NVN

AP-Tag / Avitag

EF10

mouse

human

IgG1/k

1-3

Nanobodies

Synthaxin 1a

stx1a-Nb2_K81

alpaca

rat

heavy chain IgG

1-3

in preparation

SNAP25

stx1a-Nb2_K81

alpaca

rat

heavy chain IgG

1-3

in preparation

E: ELISA; IF: Immunofluorescence; IB: Immunoblotting; IP: Immunoprecipitation; IGEM: Immunogold electron microscopy; IH: Immunohistochemistry; F: Flow cytometry; FN: Functional studies; NVN: not virus neutralizing; VN: virus neutralizing; WB: Western blotting

Reference List for monoclonal antibodies mAB

Oppermann, M., Baumgarten, H., Brandt, E., Gottsleben, W., Kurts, C., and Götze, O. (1990) J. Immunol.Methods133, 181-1902.
Oppermann, M., Kurts, C., Zierz, R., Quentin, E., Weber, M. H., and Götze, O. (1991) Kidney Int.40, 939-947.
Oppermann, M., Höpken, U., and Götze, O. (1992) Immunopharm.24, 119-134
Oppermann, M. and Götze, O. (1994) Mol. Immunol.31, 307-314
Kaiser, J., Oppermann, M., Götze, O., Deppisch, R., Göhl, H., Asmus, G., Röhrich, B., von Herrath, D., and Schäfer, K. (1994) Significant reduction of factor D and immunosuppressive complement fragment Ba by haemofiltration.
Würzner, R., Schuff-Werner, P., Franzke, A., Nitze, R.,Oppermann, M., Armstrong, V. W., Eisenhauer, T., Seidel, D., and Götze, O. (1991) Eur. J. Clin. Invest.21, 288-294.
Schuff-Werner, P., Schütz, E., Reitemeyer, F., Oppermann, M., Eisenhauer, T., Armstrong, V., Köstering, H., Götze, O., and Seidel, D. (1990) Heparin-induced extracorporeal LDL-precipitation (HELP): rheological, hemostaseological and immunological effects. In Gotto, A. M., Mancini, M., Richter, W. O., and Schwandt, P., editors. Treatment of severe hypercholesterolemia in the prevention of coronary heart disease, Basel, Karger
Oppermann, M., Haubitz, M., Quentin, E., and Götze, O. (1988) Klin. Wochenschr.66, 857-864
Püschel, G. P., Oppermann, M., Muschol, W., Götze, O., and Jungermann, K. (1989) FEBS Lett.243, 83-87
Nezlin, R., Freywald, A., and Oppermann, M. (1993) Mol. Immunol.30, 935-940
Püschel, G. P., Hespeling, U., Oppermann, M., and Dieter, P. (1993) Hepatology18, 1516-1521
Elsner, J., Oppermann, M., Czech, W., Dobos, G., Schöpf, E., Norgauer, J., and Kapp, A. (1994) C3a activates oxygen radical species production and intracellular calcium transients in human eosinophils.
Elsner, J., Oppermann, M., Czech, W., Schöpf, E., and Kapp, A. (1994) Blood83, 3324-3331.
Ammon, H. P. T., Ege, W., Oppermann, M., Göpel, W., and Eisele, S. (1995) Anal. Chem.67, 466-471
Püschel, G. P., Dieter, P., Muschol, W., Oppermann, M., Hülsmann, M., Schulze-Specking, A., Götze, O., Decker, K., and Jungermann, K. (1991) Prostanoid production in Kupffer cells: A step in the increase in glucose and lactate output and reduction of flow by anaphylatoxins in perfused rat liver. In Wisse, E., Knook, D. L., and Decker, K., editors. Cells of the hepatic sinusoid, Leiden, Kupffer Cell Foundation
Lhotta, K., Würzner, R., Kronenberg, F., Oppermann, M., and Konig, P. (1998) Kidney Int.53, 1044-1051
Höpken, U., Strüber, A., Oppermann, M., Mohr, M., Mücke, K. H., Burchardi, H., and Götze, O. (1993), Production and characterization of peptide-specific monoclonal antibodies that recognize a neoepitope on hog C5a. In Faist, E., Meakins, J., and Schildberg, F. W., editors. Host defense dysfunction in trauma, shock and sepsis, Berlin, Heidelberg, Springer Verlag.
Höpken, U., Mohr, M., Struber, A., Montz, H., Burchardi, H., Götze, O., and Oppermann, M. (1996) Eur. J. Immunol.26, 1103-1109
Oppermann, M., Schulze, M., Götze, O. (1991) A sensitive enzyme immunoassay for the quantitation of human C5a/C5a(desArg) anaphylatoxin using monoclonal antibody with specificity for a neotope. Complement Inflamm. 8 (1):13-24
Oppermann et al, J.Immunol. 1993, 151:3785-95
Schlaf et al, Lab Invest.79:1287-97
Pollok-Kopp, B. et al., J. Biol. Chem. 2003 278:2190
Ohl, L. et al., (2004) Immunity21:279-88
Ritter, U. Et al., (2004) J. Leukoc Biol., 76:472-476
Soruri, A., Kiafard, Z., Dettmer, C., Riggert, J., Kohl, J., Zwirner, J., (2003), IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo. J. Immunol. 170:3306–3314
Kiafard, Z., Tschernig, T., Schweyer, S., Bley, A., Neumannd, D., Zwirner, J., (2007), Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in tubular epithelial cells of human, murine and rat kidneys. Immunobiology, 212:129–139
Werfel, T., Kirchhoff K, Wittmann M, Begemann G, Kapp A, Heidenreich F, Götze O, Zwirner J., (2000) J Immunol., 165:6599-605.
Zwirner, J., Götze O, Begemann G, Kapp A, Kirchhoff K, Werfel T., (1999), Immunology., 97:166-72
Luhmann, A.E., et al., 2001, Mol Immunol, 38: 108 (Abstract)
Godau, J. Et al., (2004), J of Immunol., 173(5): 3437-45
Soruri, A. et al., (2003), 88: 47-52
Shushakova, N. et al, (2002), Journal Clin Invest, 110: 1823-30
Rivera-Nieves J, Ho J, Bamias G, Ivashkina N, Ley K, Oppermann M, Cominelli F. (2006), Gastroenterology. 131 (5):1518-29
Zahn, S., Zwirner, J., Spengler, H.P., Götze, O. (1997), Eur J Immunol,27(4): 935-40
Czerny, C.-P., Eichhorn, W. (1989): Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus, establishment of an efficient ELISA for antigen detection in feces. Vet.Microbiol.20: 111-122
Boulanger, D., Green, Smith, T., Czerny, C.-P., Skinner, M.A. (1998): The 131-amino-acid repeat region of the essential 39-kilodalton core protein of fowlpox virus FP9, equivalent to vaccinia virus A4L protein, is non-essential and highly immunogenic. J.Virol.72: 170-179
Isa, G., Pfister, K., Kaaden, O.-R., Czerny, C.-P. (2002): Development of a monoclonal blocking ELISA for the detection of antibodies against fowlpox virus. J.Vet.Med.B.49: 21-23.
Czerny, C.-P., Mahnel, H. (1990): Structual und functional analysis of orthopox virus epitopes. J.Gen.Virol., 71: 2341-2352.
Czerny, C.-P., Johann, S., Hölzle, H., Meyer, H. (1994): Epitope detection in the envelope of intracellular naked orthopox viruses and identification of their encoding genes. Virology200: 764-777.
Meyer, H., Osterrieder, N., Czerny, C.-P. (1994): Identification of binding sites for neutralizing monoclonal antibodies on the 14 kDa fusion protein of different orthopox virus species. Virology200: 778-783.
Czerny, C.-P., Waldmann, R., Scheubeck, T. (1997): Identification of three different antigenic sites in parapox viruses. Arch.Virol.142: 807-821.
Pollok-Kopp B., Hüttenrauch, F., Rethorn, S., Oppermann, M., J. Biol. Chem. (2007) 282:4345
Huang, C. et al. J. Biol. Chem. (2009) 284:17206
Hüttenrauch, F. et. al. (2005) J. Biol. Chem. 280:37503
Liebick M., Schläger C., Oppermann M. (2016) Analysis of Chemokine Receptor Trafficking by Site-Specific Biotinylation. PLOSOne11 (6):e0157502.