Synchronized Multi-Parameter Measurement of Contractile Cardiac Tissues for Drug Screening
This technology is a three‑modal platform that simultaneously measures calcium signals, electrical activity, and contractile force in engineered heart tissue. A shared timing system ensures precise alignment, enabling detailed analysis for cardiac drug testing and disease modeling.
Novel small molecule HDAC-inhibitor: potential game changer to fight immune evasive cancers
A novel Inhibitor binding to a specific HDAC molecule reduces the ability of tumors to hide from the immune system and increases the ability of immune cells to attack tumors. This might widen the use of promising Antibody based tumor therapies also to those cancer types, where tumors evade from the immune system.
TomoSTED – faster STED imaging at lower light doses
Tomographic STED (TomoSTED) uses a rotating 1D depletion pattern instead of the classical 2D donut shaped STED-beam. The reduction from 2D to 1D depletion results in a more robust depletion with a favourable light intensity distribution pattern, which allows to significantly reduce the overall light dose while simultaneously increasing the signal to noise ratio. Thus TomoSTED allows faster imaging while causing less bleaching while maintaining image quality.
Reducing the mortality rate of patients after Aortic-Valve Implantation by Anti-Fibrotic Treatment
A subpopulation of patients with a very high risk to die in only one year after an aortic valve implantation (AVI) was identified. A novel, anti-fibrotic treatment was developed, which adresses the most important factor for the survival rate of patients and is being tested in a phase 3 clinical trial.
Fast deconvolution of 3D Light-Sheet-Images
VALID combines theoretical considerations and the usage of empiric image data to alculate the true dimensions of the a light sheet. This allows to deconvolve a 3D image stack by a precise subtraction of the bleed-through signal between the single slices at each position of the light sheet in 3D. Furthermore, VALID extracts information allowing to define the optimal distaince between the single slices during imaging, which reduces data size and speeds up imaging itself, as well as all subsequent image processing. This approach is surperior to known deconvolutuion methods, which are either made for pointwise (e.g. confocal) imaging or use crude estimations for the 3D shape of the lightsheet.
Multi Target Drugs for treatment of Heart Failure by stabilization of Ca2+ levels
Novel Multi-Target drugs, which can modulate two key players of the Ca2+ housekeeping in heart muscle cells were jointly developed at the University Medical Center Göttingen and the MPI-NAT. The substances show increased efficiency over comparable single target RyCal drugs, which are currently under investigation in clinical trials.
Acid Cocktail for the Reduction of Campylobacter spp.
Acid Cocktail for the Reduction of Campylobacter spp. Campylobacteriosis was the most frequently reported zoonosis in the EU in 2020 and the most common cause of foodborne illness. Rare secondary diseases of a Campylobacter infection can include reactive arthritis and Guillain-Barré syndrome. After a Campylobacter infection, one in five people suffers from irritable bowel syndrome. […]
FLIX-NANOPORE for analyzing transcription factor-DNA interactions
FLIX-NANOPORE for analyzing transcription factor-DNA interactions FLIX-NANOPORE has been developed to provide the first rapid and genome-wide determination of transcription factor binding sites and transcription factor binding sequences. Transcription factors are cross-linked to DNA at the DNA binding sequence using a femtosecond laser. This is followed by proteolysis, which leaves only individual amino acids covalently […]
Increase or Inhibit Protein Production for selected Genes
Increase or Inhibit Protein Production for selected Genes Our cutting-edge technology revolutionizes gene regulation by precisely controlling the translation of specific target genes. By modulating the nuclear export of corresponding mRNA, we can either enhance or inhibit gene expression with remarkable specificity. This innovation stems from breakthrough research revealing how defined anti-sense RNAs bind to […]
New Nanobody vs CD38 outperforms FDA-approved Antibodies for treatment of multiple Myeoloma
New Nanobody vs CD38 outperforms FDA-approved Antibodies for treatment of multiple Myeoloma A new single domain antibody (Nanobody NbC6) against CD38 shows superior properties over FDA-approved Antibodies like Isatuximab and Daratumumab. Its Higher Affinity, smaller size and improved killing efficiency makes it a superior candidate for treatment of Multiple Myeoloma. Additionally, a combination with at […]