Specific DPP8 and/or DPP9 inhibitors
Dipeptidyl peptidases (DPP's) are essential for many biological processes and are therefore intensively studied within the research community. For this, inhibitors are critically in understanding key functions of this particular family of peptidases. The active site of all members of the DPP-IV family is highly conserved making it difficult to design specific inhibitors.
All available inhibitors the DPP IV family target the catalytic site of these enzymes, acting as competitive inhibitors. As the active site of all members of this family is highly conserved, current inhibitors always show residual activity against other DPPIV homologous. Accordingly, there is still an unmet need for inhibitors that can differentiate between members of the DDPIV family, preferably between DPP8 and DPP9. This is a prerequisite for a selective cancer therapy based on DPP8/9 inhibition.
Scientists at the University of Göttingen developed new and for the first time specific inhibitors of dipeptidyl peptidase 8 and 9, without inhibiting other members of the dipeptidyl peptidase 4 family. The peptide inhibitors show anti-proliverative properties demonstrating their therapeutical usage in cancer therapies.
In vitro proof of concept.
A US patent has been granted (Patent holder: University of Göttingen public law foundation).
Dr. Stefan Uhle