Tissue engineering has advanced over the last two decades and has the potential to replace traditional cell-based assays. Today, preclinical drug or toxin screening still relies on cell culture with poor predictive power. Scientists at the University of Göttingen have developed a new device for automated and reliable tissue engineering and drug testing.
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FLIX-NANOPORE has been developed to provide the first rapid and genome-wide determination of transcription factor binding sites and transcription factor binding sequences. Transcription factors are cross-linked to DNA at the DNA binding sequence using a femtosecond laser. This is followed by proteolysis, which leaves only individual amino acids covalently bound to their DNA-binding sequence. In the nanopore, the complexes of covalently bound amino acids and nucleobases are sequenced simultaneously, allowing us to identify the transcription factor binding sites and the corresponding sequence.
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Our smart ventilation tube revolutionizes the monitoring and control of patient ventilation in anaesthesiology, emergency and intensive care medicine. By integrating a MEMS microphone and a suction channel, it enables precise recording and analysis of of respiratory and ventilation parameters in real time. Using advanced detection algorithms, the tube provides medical staff with important information and recommendations to improve the quality of care and detect abnormalities in ventilation at an early stage.
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The evaluation of the pentafluorocyclopropyl group as a chemotype in crop protection and medicinal chemistry has been hampered in the past by the lack of suitable methodologies that enable the practical incorporation of this moiety into advanced synthetic intermediates. By synthesizing an unprecedented sulfonium salt, 5-(pentafluorocyclopropyl)-dibenzothiophenium triflate, and using it as a versatile reagent for photoinduced pentafluorocyclopropylation, a wide range of (hetero)arenes are enabled by a radical-mediated mechanism.
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