Animal model for arthritic diseases

Written by Martin Groß on 21 January 2017.

Animal model for arthritic diseases

Arthritic diseases are conditions involving damages to the joints and/or cartilage. A primary form of arthritis is for example rheumatoid arthritis, which affects over 21 million people worldwide. Scientists at the University of Göttingen have developed a new animal drug screening model for arthritic diseases.

Prodrugs/drugs for a selective ADC tumor therapy

Written by Martin Groß on 21 October 2016.

Prodrugs/drugs for a selective ADC tumor therapy

Scientists at the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-molar range) as well as a selective tumor therapy through their prodrugs. Selectivity is achieved by antibody tumor targeting. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site.