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About us

MBM ScienceBridge GmbH evaluates, protects and commercializes inventions of higher education institutions and research facilities. It was founded as a private company and wholly owned subsidiary of the University of Göttingen Public Law Foundation in 2004.

We see our mission in the motivation of scientists to also look at their own research results from the perspective of an economically relevant invention and to report such to the employer as an employee invention.

In the case of promising inventions, we coordinate the application for an intellectual property right with external patent lawyers who are specialised in the relevant field

We subsequently present such inventions worldwide to companies in order to identify partners who are interested in developing the invention into a product and placing the product onto the market

Drug Delivery Vehicle/Plattform into brain

Novel vehicle platform for the targeted delivery of drugs into the brain parenchyma, particularly useful as platform for the delivery of biologics, like e.g. proteins or antibodies. 


The delivery of drugs into the brain, particularly of (big) biologicals, is hampered by the blood-brain-barrier (BBB) as well as CSF-brain-barrier. Specially naked protein delivery into e.g. CSF might show undesired immunogenic side effects (e.g. meningitis). Current state-of-the-art, like liposomes, has an inefficient delivery of biologicals (like proteins and antibodies) from plasma to CSF and brain. Delivery pumps with direct protein delivery into CSF often result in meningitis and inflammatory response. Vector based delivery systems have the disadvantage that they should be applied by injection all over the brain, as well as the control of the vector.

Our Solution

Scientists at the Universitätsmedizin Göttingen developed a designed delivery vesicle as cargo transport of drugs with higher molecular weight and of biologicals like e.g. proteins or antibodies, for targeted delivery into brain parenchyma. The targeting is achieved through a specific biomarker, which is incorporated into the designed vesicles. When the biomarker is located on the surface of vesicles it enables penetration and distribution of vesicles into brain parenchyma. The biomarker plays an important role in the natural brain delivery (see references). This novel vesicles could be used as a carrier and delivery technology platform.


  • Safe delivery of biologicals into the brain parenchyma.
  • Vesicles shield payload from immunogenic effects.
  • High capacity transport and delivery.
  • Specific targeting of the brain parenchyma with our specific biomarker.
  • Good biodistribution within the brain


Technology platform to be used for the delivery of biologicals, like proteins or antibodies, or drugs with higher molecular weight, into the brain, for the therapy of neurological, neurodegenerative and neuronal metabolic diseases.

Developmental Status

Preclinical research in vitro and in vivo, with in vivo proof of principle.

Patent Status

US20140105817A1 and EP2908800A1 patent applications have been filed. Applicants are the Georg-August-University - Medical Center Göttingen together with the Göttinger start-up AllOrphan UG.


Nature Commun. (2013) 4:2123 doi: 10.1038/ncomms3123, Grapp et al.


Dr. Stefan Uhle
Patent Manager Life Sciences
E-Mail: suhle(at)sciencebridge.de
Tel.: +49-551-30724154
Reference: BioT-1539-SUG

Tags: Therapy

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MBM ScienceBridge GmbH supports scientists, evaluates inventions, oversees applications for intellectual property rights and out-licenses patents of universities and research institutions in Göttingen and Lower Saxony.

Our company evaluates, protects and commercializes inventions of higher education institutions and research facilities. It was founded as a private company and wholly owned subsidiary of the University of Göttingen, Public Law Foundation, in 2004.

Office of MBM ScienceBridge GmbH:
The office of the MBM ScienceBridge GmbH resides in the Laser Laboratory on the northern campus of the Georg-August-University Göttingen.

A subsidiary of

Georg-August-Universität Göttingen