New bifunctional Prodrugs with cleavable linker for targeted tumor therapy (ADC)
Antibody tumor therapies have provided therapeutic benefit to patients with cancer, autoimmune diseases and other serious medical conditions. However, many antibodies lack sufficient intrinsic anti-tumor activity to be used as first-line therapeutics. Scientists at the University of Göttingen developed new and highly potent drugs with cleavable chemical linkers to develop tumor specific antibodies for selective and highly effective tumor therapy (ADC).
Selective tumor therapy combines the benefits from classical chemotherapy and antibody tumor therapy by providing antibody-drug-conjugates (ADC). These conjugates must provide safe medical application (prodrugs) and extremely high toxicity within the targeted tumor cell (activated drug). Thus, there is a high medical unmet need to provide ADCs with stable but cleavable chemical linker to safely and effectively release highly toxic payloads.
Scientists at the University of Göttingen developed new and highly potent prodrugs/drugs with cleavable chemical linkers for ADCs. The soluble prodrugs are activated into highly cytotoxic drugs (IC50 in the pico-molar range) only in targeted tumor cells.
Our 2nd generation bifuncional prodrug with two CBI alkylation units (CBI = cyclopropabenzindole).
New chemical linker design to antibodies based on our 2nd generation bifuncional prodrugs/drugs. A) Linkage via CBI alkylation unit. Since there are two CBI units in the full molecule, linkage of two antibodies are possible. B) Linkage via CBI linker unit.
ADC Tumor Therapy.
In vitro tested prodrugs/drugs having cleavable linker for direct antibody coupling.
An international patent application has been filed and a new patent application (improvement) will be filed. (WO2017072295A1, Applicant: Georg-August-University of Göttingen public law foundation).
DE102009051799A1 (2nd generation bifunctional prodrugs/drugs (Duocarmycin origin).
Dr. Stefan Uhle