Mouse model for arthritic diseasesArthritic diseases are conditions involving damages to the joints and/or cartilage. Primary forms of arthritis are for example Osteoarthritis, Rheumatoid arthritis (RA) and Ankylosing spondylitis. RA is affecting over 21 million people worldwide and has a tumor-like proliferation phenotype. ChallengeTraditional approaches for treatment of arthritis are typically not suitable for long-term use due to side effect issues. So there is an unmet clinical need for new medications. Our SolutionDeletion of Ptch1 in chondrocytes results in a severe spinal phenotype. Macroscopic image of litter mates eight weeks after birth. Volume rendering of in vivo acquired flat-panel volume computed tomography data sets depicting skeletal morphology of control (left) and mutant (right) 6 weeks after birth. Lower panels show bone density.
Advantages
ApplicationsExcellent drug screening model for new targets within Hedgehog signaling. Developmental StatusFully characterized new mouse model for arthritic diseases. Patent StatusNo IPR. We are selling/licensing this mouse model. ReferencesDittmann et al.: Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation. Arthritis Rheumatol. 2014 Apr;66(4):831-40. ContactDr. Stefan Uhle |