Mouse model for arthritic diseases
Arthritic diseases are conditions involving damages to the joints and/or cartilage. Primary forms of arthritis are for example Osteoarthritis, Rheumatoid arthritis (RA) and Ankylosing spondylitis. RA is affecting over 21 million people worldwide and has a tumor-like proliferation phenotype.
Traditional approaches for treatment of arthritis are typically not suitable for long-term use due to side effect issues. So there is an unmet clinical need for new medications.
Deletion of Ptch1 in chondrocytes results in a severe spinal phenotype. Macroscopic image of litter mates eight weeks after birth.
Volume rendering of in vivo acquired flat-panel volume computed tomography data sets depicting skeletal morphology of control (left) and mutant (right) 6 weeks after birth. Lower panels show bone density.
Excellent drug screening model for new targets within Hedgehog signaling.
Fully characterized new mouse model for arthritic diseases.
No IPR. We are selling/licensing this mouse model.
Dittmann et al.: Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation. Arthritis Rheumatol. 2014 Apr;66(4):831-40.
Dr. Stefan Uhle