Pan-Coronavirus Therapy using a Cas13-guideRNA system. The antiviral effect is based on up to 5 Cas13-guideRNAs, which target and disrupt the Coronavirus RNA genome in all currently known variations, resulting in a complete blocking of viral replication in lung cells after 24h.
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Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy (TBX5 re-expression) for use in the prevention and acute treatment of a heart disease and associated complications (e.g. cardiac arrhythmia and sudden cardiac death).
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Regenerative medicine is the replacement of diseased tissues with tissue engineered products (TEPs). Stem cells have emerged as the most important source for TEPs. However they carry the risk of uncontrolled cell growth. To solve this problem the present invention uses radiation for mitotic inactivation without loss of function.
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We developed first row transition metal ions (i.e. Fe/ iron) supported by macrocyclic ligands to provide alternatives to lanthanide contrast agents for MRI- thus NOT using gadolinium. The tripodal Schiff base ligands provide water-soluble coordination complexes with i.e. iron, providing signal contrast in MRI.
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Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of a therapeutic factor (i.e. GDNF) with zero background expression, based on mifepristone (Mfp)-Gene Switch system, for the therapy of neurological diseases.
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All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e. in heart, kidney, liver, lung, cancer). Normal re-expression of these genes has been achieved successfully in vitro and in vivo as well as a reduction of fibrosis.
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Prevention of Fibrosis and Organ Protection by preconditioning cells via ARNT regulation, i.e. via low-dose tacrolimus, GPI-1046, LB100 or via gene-therapy.
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Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded AAV virus mediated delivery into the cochlea. In vivo proof-of-concept successfully achieved.
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Scientists at the University of Veterinary Medicine Hanover, Germany developed a new test for a genetic defect causing bleeding disorders in dogs. It allows breeders to improve targeted mating by omitting genetic carriers to avoid genetic diseases in offsprings. This is especially important for autosomal recessive mutations.
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Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses with improved DIVA (Differentiating Infected from Vaccinated Animals) properties. The used marker Erns is a chimeric sequence of two different and remotely related pestiviruses.
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Zellweger Syndrome spectrum, an orphan disease, is a peroxisomal biogenesis disorder with no treatment currently available. We offer the use of the clinically known Laquinimod (developed for multiple sclerosis) for the therapy of Zellweger Syndrom, for which we achieved successfully an in vivo proof-of-concept.
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Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production of human bio-engineered neuronal organoids (BENOs) from stem cells. This new method will allow for reproducible production of oganoids with fully functional neuronal network activity.
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Scientists at the University of Göttingen in Germany developed new and highly potent drugs with cleavable chemical linkers to develop tumor specific antibodies for selective tumor therapy (ADC). The soluble prodrugs are activated into highly cytotoxic drugs only in targeted tumor cells.
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Heart tissue engineering using stem cells is a recently developed technique to construct a three dimensional cell structure from cardiomyocytes or directly from progenitor cells. Scientists at the University of Göttingen developed two new and fully defined methods for serum-free production of engineered human heart muscles.
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Die Reduktion von klimaschädlichen CO2 ist eine der dringendsten Aufgaben für eine umweltfreundliche und nachhaltige Energiegewinnung. Biotechnologische Ansätze haben hier einen hohen Stellenwert erlangt. Wissenschaftler der Universität Göttingen entwickelten einen neuen Biokatalysator zur CO2-Fixierung.
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The EYA1 splicing was found to be linked with the progression of fibrosis. Patients expressing predominantly EYA1-A ("bad" variant) end up in the end stage renal disease earlier and suffer from a higher mortality. A shift of splicing towards EYA1-C ("good" variant) effectively attenuates fibrosis in vivo (mouse model).
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Shar-Pei Autoinflammatory Disease (SPAID) is a complex inflammatory disease. Typical signs are recurrent bouts of fever, inflammations of the ear, arthritis and a reddened skin. The dogs can also develop amyloidosis. Scientists at the University of Veterinary Medicine Hannover developed a genetic test for SPAID predisposition.
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Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.
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Scientists at the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-molar range) as well as a selective tumor therapy through their prodrugs. Selectivity is achieved by antibody tumor targeting. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site.
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Scientists of the University of Göttingen and of the University of Regensburg developed in collaboration a proprietary anti-CCR2 antibodies for the therapy of Multiple Sclerosis (MS) and potentially Rheumatoid Arthritis (RA).The lead candidate Doc-2 has been humanized in collaboration with the MRC Technologies. It targets the CCR2 receptor and modulates the autoimmune process through depletion of CCR2+ monocytes.
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Mastitis continues to be the most important economic risk for dairy farmers. Current treatment rely heavily on antibiotics, which is costly and frequently ineffective due to increased spread of antibiotic resistance. Scientists at the University of Applied Sciences and Arts Hannover developed a probiotic and protective teat dip.
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Scientists of the University of Göttingen developed a novel vehicle for the targeted delivery of drugs into the brain parenchyma, particularly useful for the delivery of biologics, like e.g. proteins or antibodies.
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New transgenic mouse model for sporadic Alzheimer's Disease. It does not have any mutation and it shows neurological deficits by transgenic over-expressing a major form of amyloid beta peptides (N-truncated Abeta 4-42) found in the brain of AD patients.
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Peptidases are essential for many biological processes and are therefore intensively studied within the research community. Scientists at the University of Göttingen developed new and for the first time specific inhibitors of dipeptidyl peptidase 8 and 9, without inhibiting other members of the dipeptidyl peptidase 4 family.
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Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease is one of the most common degenerative neuromuscular diseases worldwide and characterized by rapidly progressive weakness and muscle atrophy throughout the body. Scientists at the University of Göttingen developed a new neuroprotective therapeutic approach for ALS.
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Scientists at the University of Göttingen developed a novel, proprietary antibody for the therapy and/or diagnosis of Alzheimer's Disease (AD) through the targeting of specifically pyro-Glu-Amyloid beta peptides.
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Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. GISTs occur in 10-20 per one million people. Thus, GIST has been named as an orphan drug disease. Scientists at the University of Göttingen developed a new animal drug screening model for GIST.
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Paratuberculosis or Johne's disease is a contagious, chronic and also fatal bacterial infection, which generally occurs early in life. The disease can exist undetected in a herd for many years. Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis.
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Arthritic diseases are conditions involving damages to the joints and/or cartilage. A primary form of arthritis is for example rheumatoid arthritis, which affects over 21 million people worldwide. Scientists at the University of Göttingen have developed a new animal drug screening model for arthritic diseases.
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Oils and fats are the most important raw materials for the chemical industry. Modern biotechnology methods are now extensively applied to fatty acid compounds for selective functionalization of alkyl chains. Scientists at the University of Göttingen isolated and developed new enzymes for strategic transformation of fatty acids.
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The Culture Collection of Algae at the Georg August University Göttingen is one of the five largest collections of living microscopic algae. Founded in 1954, the SAG collection today holds around 2.250 strains from almost all evolutionary lineages of algae and cyanobacteria (1202 named species from 521 genera), mostly isolated from freshwater or terrestrial habitats.
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Scientists at the University of Göttingen have developed a variety of monoclonal antibodies, which are used for research purposes, but also find applications in the development of diagnostic tests and therapeutic solutions. Here you will find a list of all antibodies that currently are available for licensing. Details
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