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TomoSTED – faster STED imaging at lower light doses
Tomographic STED (TomoSTED) uses a rotating 1D depletion pattern instead of the classical 2D donut shaped STED-beam. The reduction from
Reducing the mortality rate of patients after Aortic-Valve Implantation by Anti-Fibrotic Treatment
A subpopulation of patients with a very high risk to die in only one year after an aortic valve implantation
Fast deconvolution of 3D Light-Sheet-Images
VALID combines theoretical considerations and the usage of empiric image data to alculate the true dimensions of the a light
Multi Target Drugs for treatment of Heart Failure by stabilization of Ca2+ levels
Novel Multi-Target drugs, which can modulate two key players of the Ca2+ housekeeping in heart muscle cells were jointly developed
Novel small molecule HDAC-inhibitor: potential game changer to fight immune evasive cancers
A novel Inhibitor binding to a specific HDAC molecule reduces the ability of tumors to hide from the immune system
Dynamic Microconfiner: Biomimetic 3D cell culture
Novel Micronfiner for the first time allows to create a topological, mechanical and chemical controlled cell culture system for reproducible
Mouse model for arthritic diseases
Scientists of the University of Göttingen developed a transgenic mouse model for sporadic Alzheimer's Disease (tg4-42 = TBA83). This is
Antibodies for Licensing
Chemokine receptors undergo internalization and desensitization in response to ligand activation. Internalized receptors are either preferentially directed towards recycling pathways
Method to visualize proteins and protein-complexes with sizes of less than 1nm
Researchers in the Rizzoli Lab at the university Göttingen developed a method which allows to visualize protein-protein interactions and might
A new combination therapy of pyrimidine analogues and pyrimidine biosynthesis inhibitors to combat RNA virus infections like Sars-CoV-2
This is a combined therapeutic approach for treating and/or preventing RNA viral infections using a pyrimidine biosynthesis inhibitor in combination
Novel Channelrhodopsin with increased and stabilized photocurrent
By structure guided rational mutagenesis a superior Channelrhodopsin variant (ChReef) was developed from the Protein ChRmine. A desensitization effect could
New approach to treat patients suffering from Noonan-Syndrome
A new single domain antibody (Nanobody NbC6) against CD38 shows superior properties over FDA-approved Antibodies like Isatuximab and Daratumumab. Its
Pan-Coronavirus Therapy – a Cas13-based antiviral approach
Scientists from the University of Göttingen developed a strategy for a therapy which will work against all Coronaviruses known to
Formteile für Tiernahrung für Hunde und Katzen mit ausgezeichnetem Geschmack und niedrigem Kalorienwert.
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Trockenfutterartikeln für Haustiere aus gepufftem Mais in allen möglichen Formen und
Dopamine producing organoids for therapy of Parkinson’s Disease
Researchers at the University Medical Center in Göttingen, Germany, have developed a method to produce special brain organoids called "dopamine-producing
Novel bacterial Cry proteins for treating parasitic nematodes in humans and animals
Gastrointestinal nematode (GIN) infections are a significant issue, particularly in animals that graze. They can have a severe impact on
Activity-improved human Asparaginase for Cancer therapy
Amino acid depletion therapy offers a promising approach to cancer treatment. It makes use of the differences between healthy and
New Nanobody vs CD38 outperforms FDA-approved Antibodies for treatment of multiple Myeoloma
A new single domain antibody (Nanobody NbC6) against CD38 shows superior properties over FDA-approved Antibodies like Isatuximab and Daratumumab. Its
FLIX-NANOPORE for analyzing transcription factor-DNA interactions
FLIX-NANOPORE has been developed to provide the first rapid and genome-wide determination of transcription factor binding sites and transcription factor
Acid Cocktail for the Reduction of Campylobacter spp.
Campylobacteriosis was the most frequently reported zoonosis in the EU in 2020 and the most common cause of foodborne illness.
Tissue-engineered Human Heart Muscle from stem cells for Screening and for Heart Repair
Heart tissue engineering using stem cells is a recently developed technique to construct a three dimensional cell/tissue structure from progenitor
Improved PCR Diagnostic for detection of Paratuberculosis (or Johne’s disease)
Mycobacterium avium subspecies paratuberculosis (MAP) is the organism responsible for a chronic, intestinal inflammatory disease found in domestic livestock, including
Bio-engineered neuronal organoids from human stem cells
In vitro 3D modeling of neural tissues represents a powerful tissue bioengineering tool permitting the study of complex neuronal cell
Pharmacologically controlled vector for CNS gene therapies
Current gene therapy is irreversible and does not allow controlled transgene expression in case of side effects. The invention is
Synthesis of prodrugs with cleavable linker for targeted tumor therapy (ADC)
Antibody tumor therapies have provided great therapeutic benefit to patients with cancer, autoimmune diseases and other serious medical conditions. However,
Algensammlung der Universität Göttingen (SAG)
Die Sammlung von Algenkulturen an der Universität Göttingen (SAG) ist eine der weltweit größten Sammlungen von lebenden mikroskopisch kleinen Algen.
New Genetic Test for Bleeding disorders in Dogs
Genetic tests are playing an increasingly important role in today's dog breeding. They allow breeders to improve targeted mating in
Targeted Demethylating Gene Therapy of Fibrosis
All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e. in heart, kidney,
Therapy of Alzheimer’s Disease with an antibody against oligomeric pyro-Glu-Abeta peptides
Scientists at the University of Göttingen developed a novel, proprietary antibody for the therapy and/or diagnosis of Alzheimer's Disease (AD)
Animal model for Gastrointestinal Stromal Tumor (GIST)
Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. GISTs occur in 10-20
Animal model for sporadic Alzheimer’s Disease
Scientists of the University of Göttingen developed a transgenic mouse model for sporadic Alzheimer's Disease (tg4-42 = TBA83). This is
New Genetic Test for Shar-Pei Autoinflammatory Disease (SPAID)
SPAID is a spontaneously occurring autoinflammatory disease in Shar-Pei dogs. It is characterized by recurrent signs of inflammation like fever,
Prodrugs and drugs for selective ADC tumor therapy
Antibody tumor therapies have provided therapeutic benefit to patients with cancer, autoimmune diseases and other serious medical conditions. However, many
