Device for culture and measure tissue engineered products

Scalable device for culturing and automatically measuring tissue engineered products

Tissue engineering has advanced over the last two decades and has the potential to replace traditional cell-based assays. Today, preclinical drug or toxin screening still relies on cell culture with poor predictive power. Scientists at the University of Göttingen have developed a new device for automated and reliable tissue engineering and drug testing.

Antiviral combination therapy for RNA viruses (e. g. Sars)

Combination therapy for RNA virus diseases with pyrimidine synthesis inhibitors and nucleotide analogues

The COVID-19 pandemic has emerged as the most serious health crisis in modern times. To combat RNA viral infections like SARS, Influenza, Hepatitis C, HIV or even Ebola a new combination therapeutic approach of pyrimidine analogues and pyrimidine biosynthesis inhibitors has been discovered.

Novel high current Channelrhodopsins

Improved Channelrhodopsins for future Optogenetic Therapies

By structure guided rational mutagenesis a superior Channelrhodopsin variant (ChReef) was developed from the Protein ChRmine. A desensitization effect could be reduced by a factor of three and at the same time the light induced photo-current of these variants is five times higher. This allows for an activation of neurons with lower light doses and/or a reduced expression level, which will reduce side effects.

New approach for Ligh-Sheet-Deconvolution

Fast deconvolution of 3D Ligh-Sheet Images (VALID)

Vertical Algebraic LIght sheet Deconvolution (VALID) combines theoretical considerations and the usage of empiric image data for deconvolving 3D image stacks. By using an iterative approach, VALID is able calculate the true dimensions of a light sheet, which allows to precisely subtract bleed-through signal between the single slices - at each position of the light sheet in 3D.