Life science

Treatment of cardiac arrhythmia via re-expression of TBX5 (gene therapy)

Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy (TBX5 re-expression) for use in the prevention and acute treatment of a heart disease and associated complications (e.g. cardiac arrhythmia and sudden cardiac death).

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Pharmacologically controlled vector for CNS gene therapies

Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of a therapeutic factor (i.e. GDNF) with zero background expression, based on mifepristone (Mfp)-Gene Switch system, for the therapy of neurological diseases.

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Targeted Demethylating Gene Therapy of Fibrosis

All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e. in heart, kidney, liver, lung, cancer). Normal re-expression of these genes has been achieved successfully in vitro and in vivo as well as a reduction of fibrosis.

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Prevention and treatment of of Fibrosis and Chronic Injury progression

Prevention or treatment of Fibrosis and Organ Protection via ARNT regulation

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1-vector otoferlin DFNB9 gene therapy

Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded AAV virus mediated delivery into the cochlea. In vivo proof-of-concept successfully achieved.

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New Genetic Test for Bleeding disorders in Dogs

Scientists at the University of Veterinary Medicine Hanover, Germany developed a new test for a genetic defect causing bleeding disorders in dogs. It allows breeders to improve targeted mating by omitting genetic carriers to avoid genetic diseases in offsprings. This is especially important for autosomal recessive mutations.

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Improved marker vaccine against classical swine fever

Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses with improved DIVA (Differentiating Infected from Vaccinated Animals) properties. The used marker Erns is a chimeric sequence of two different and remotely related pestiviruses.

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Leucodistrophy-Repositioning: Laquinimod for Zellweger-Syndrome

Zellweger Syndrome spectrum, an orphan disease, is a peroxisomal biogenesis disorder with no treatment currently available. We offer the use of the clinically known Laquinimod (developed for multiple sclerosis) for the therapy of Zellweger Syndrom, for which we achieved successfully an in vivo proof-of-concept.

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Bio-engineered neuronal organoids from human stem cells

Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production of human bio-engineered neuronal organoids (BENOs) from stem cells. This new method will allow for reproducible production of oganoids with fully functional neuronal network activity.

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Improved PCR Diagnostic for detection of Paratuberculosis (or Johne’s disease)

Paratuberculosis or Johne's disease is a contagious, chronic and also fatal bacterial infection, which generally occurs early in life. The disease can exist undetected in a herd for many years. Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis.

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EYA1 — Biomarker and therapeutic target for kidney fibrosis

The EYA1 splicing was found to be linked with the progression of fibrosis. Patients expressing predominantly EYA1-A ("bad" variant) end up in the end stage renal disease earlier and suffer from a higher mortality. A shift of splicing towards EYA1-C ("good" variant) effectively attenuates fibrosis in vivo (mouse model).

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New Genetic Test for Shar-Pei Autoinflammatory Disease (SPAID)

Shar-Pei Autoinflammatory Disease (SPAID) is a complex inflammatory disease. Typical signs are recurrent bouts of fever, inflammations of the ear, arthritis and a reddened skin. The dogs can also develop amyloidosis. Scientists at the University of Veterinary Medicine Hannover developed a genetic test for SPAID predisposition.

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Monoclonal antibodies against biotinylated AP-tag / Avi Tag

Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.

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Humanized anti-CCR2 Antibody for the Therapy of MS and RA

Scientists of the University of Göttingen and of the University of Regensburg developed in collaboration a proprietary anti-CCR2 antibodies for the therapy of Multiple Sclerosis (MS) and potentially Rheumatoid Arthritis (RA).The lead candidate Doc-2 has been humanized in collaboration with the MRC Technologies. It targets the CCR2 receptor and modulates the autoimmune process through depletion of CCR2+ monocytes.

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Animal model for sporadic Alzheimer’s Disease

New transgenic mouse model for sporadic Alzheimer's Disease. It does not have any mutation and it shows neurological deficits by transgenic over-expressing a major form of amyloid beta peptides (N-truncated Abeta 4-42) found in the brain of AD patients.

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Pet food mouldings for dogs and cats with excellent taste and low caloric value

The present invention relates to a method for producing dry pet food articles from puffed corn in all kinds of shapes and forms with good taste and low caloric value.

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New therapeutic target against bacterial or viral infections

Targeting key proteins in viral or bacterial pathogens is an appealing way to combat infectious diseases. A new protein domain has been discovered as a therapeutic target.

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Therapy of Alzheimer's Disease with an antibody against oligomeric pyro-Glu-Abeta peptides

Scientists at the University of Göttingen developed a novel, proprietary antibody for the therapy and/or diagnosis of Alzheimer's Disease (AD) through the targeting of specifically pyro-Glu-Amyloid beta peptides.

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Animal model for Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. GISTs occur in 10-20 per one million people. Thus, GIST has been named as an orphan drug disease. Scientists at the University of Göttingen developed a new animal drug screening model for GIST.

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Animal model for arthritic diseases

Arthritic diseases are conditions involving damages to the joints and/or cartilage. A primary form of arthritis is for example rheumatoid arthritis, which affects over 21 million people worldwide. Scientists at the University of Göttingen have developed a new animal drug screening model for arthritic diseases.

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Culture Collection of Algae of Göttingen University (SAG)

The Culture Collection of Algae at the Georg August University Göttingen is one of the five largest collections of living microscopic algae. Founded in 1954, the SAG collection today holds around 2.250 strains from almost all evolutionary lineages of algae and cyanobacteria (1202 named species from 521 genera), mostly isolated from freshwater or terrestrial habitats.

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Antibodies for Licensing

Scientists at the University of Göttingen have developed a variety of monoclonal antibodies, which are used for research purposes, but also find applications in the development of diagnostic tests and therapeutic solutions. Here you will find a list of all antibodies that currently are available for licensing. Details

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