Scalable device for culturing and automatically measuring tissue engineered products
Tissue engineering has advanced over the last two decades and has the potential to replace traditional cell-based assays. Today, preclinical drug or toxin screening still relies on cell culture with poor predictive power. Scientists at the University of Göttingen have developed a new device for automated and reliable tissue engineering and drug testing.
Kombi-Therapie für RNA-Virus-Erkrankungen mit Pyrimidin-Synthesehemmern und Nukleotidanaloga
Die COVID-19-Pandemie hat sich als die schwerste Gesundheitskrise der Neuzeit erwiesen. Zur Bekämpfung von RNA-Virusinfektionen wie SARS, Influenza, Hepatitis C, HIV und sogar Ebola wurde ein neuer kombinierter therapeutischer Ansatz aus Pyrimidin-Analoga und Pyrimidin-Biosynthese-Hemmern entwickelt.
Combination therapy for RNA virus diseases with pyrimidine synthesis inhibitors and nucleotide analogues
The COVID-19 pandemic has emerged as the most serious health crisis in modern times. To combat RNA viral infections like SARS, Influenza, Hepatitis C, HIV or even Ebola a new combination therapeutic approach of pyrimidine analogues and pyrimidine biosynthesis inhibitors has been discovered.
Durch rationale Mutagenese wurde das vor kurzem entdeckte Kanalrhodopsin ChRmine verbessert. Die neue Varainte "ChReef" erzeugt gegenüber dem derzeit in klinischen Studien verwnedeten ChrimsonR einen um den Faktor neun höheren Photoström. Dies ermöglicht eine Aktivierung von Neuronen mit geringeren Lichtdosen und/oder einem reduzierten Expressionsniveau, was zu einer Verringerung der Nebenwirkungen führt.
Improved Channelrhodopsins for future Optogenetic Therapies
By structure guided rational mutagenesis a superior Channelrhodopsin variant (ChReef) was developed from the Protein ChRmine. A desensitization effect could be reduced by a factor of three and at the same time the light induced photo-current of these variants is five times higher. This allows for an activation of neurons with lower light doses and/or a reduced expression level, which will reduce side effects.
Multi-Target Wirkstoffe stabilisieren Ca2+ Level in Herzzellen
Neu entwickelte Wirkstoffe stabilisieren den Ca2+ Level in Muskelzellen und können so Herzfehlern vorbeugen. Die potentiellen Medikamente erlauben eine gleichzeitige Anpassung der Aktivität von den Proteinen RyR2 und SERCA, welche Schlüsselrollen im Ca2+ Signalweg haben.
Multie Target drugs stabilize Ca2+ levels to prevent heart failure
Newly developed drugs stabilize the Ca2+ level in heart muscle cells and can prevent heart failure. These novel drug-candidates allow a simultaneous modulation of the function of the two transporters RyR2 and SERCA, which have key roles in the Ca2+ housekeeping and signaling pathway.
Dynamic Microconfiner Microconfiner allows 2D cell culture mimicking 3D conditions in living organisms
A novel Micronfiner for the first time allows to create a topological, mechanical and chemical controlled cell culture system for reproducible bio-mimetic culture conditions.
Pet food mouldings for dogs and cats with excellent taste and low caloric value
The present invention relates to a method for producing dry pet food articles from puffed corn in all kinds of shapes and forms with good taste and low caloric value.
FLIX-NANOPORE for analyzing transcription factor-DNA interactions
FLIX-NANOPORE has been developed to provide the first rapid and genome-wide determination of transcription factor binding sites and transcription factor binding sequences. Transcription factors are cross-linked to DNA at the DNA binding sequence using a femtosecond laser. This is followed by proteolysis, which leaves only individual amino acids covalently bound to their DNA-binding sequence. In the nanopore, the complexes of covalently bound amino acids and nucleobases are sequenced simultaneously, allowing us to identify the transcription factor binding sites and the corresponding sequence.
FLIX-NANOPORE zur Analyse von Transkriptionsfaktor-DNA-Interaktionen
FLIX-NANOPORE wurde entwickelt, um erstmals eine schnelle und genomweite Bestimmung von Bindungsstellen und Bindungssequenzen von Transkriptionsfaktoren zu ermöglichen. Die Transkriptionsfaktoren werden mit einem Femtosekundenlaser an der DNA-Bindungssequenz quervernetzt. Anschließend erfolgt eine Proteolyse, bei der nur einzelne Aminosäuren kovalent an ihre DNA-Bindesequenz gebunden werden. In der Nanopore werden die Komplexe aus kovalent gebundenen Aminosäuren und Nukleobasen gleichzeitig sequenziert, so dass wir die Bindungsstellen des Transkriptionsfaktors und die entsprechende Sequenz identifizieren können.
GMP-compatible Methods for producing tissue-engineered human heart muscle from stem cells
Heart tissue engineering using stem cells is a recently developed technique to construct a three dimensional cell structure from cardiomyocytes or directly from progenitor cells. Scientists at the University of Göttingen developed two new and fully defined methods for serum-free production of engineered human heart muscles.
Improved marker vaccine against classical swine fever
Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses with improved DIVA (Differentiating Infected from Vaccinated Animals) properties. The used marker Erns is a chimeric sequence of two different and remotely related pestiviruses.
Therapy of Alzheimer's Disease with an antibody against oligomeric pyro-Glu-Abeta peptides
Scientists at the University of Göttingen developed a novel, proprietary antibody for the therapy and/or diagnosis of Alzheimer's Disease (AD) through the targeting of specifically pyro-Glu-Amyloid beta peptides.
Animal model for Gastrointestinal Stromal Tumor (GIST)
Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. GISTs occur in 10-20 per one million people. Thus, GIST has been named as an orphan drug disease. Scientists at the University of Göttingen developed a new animal drug screening model for GIST.
New transgenic mouse model for sporadic Alzheimer's Disease. It does not have any mutation and it shows neurological deficits by transgenic over-expressing a major form of amyloid beta peptides (N-truncated Abeta 4-42) found in the brain of AD patients.
Arthritic diseases are conditions involving damages to the joints and/or cartilage. A primary form of arthritis is for example rheumatoid arthritis, which affects over 21 million people worldwide. Scientists at the University of Göttingen have developed a new animal drug screening model for arthritic diseases.
Scientists at the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-molar range) as well as a selective tumor therapy through their prodrugs. Selectivity is achieved by antibody tumor targeting. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site.
