Therapy

Antivirale Kombi-Therapie gegen RNA viren (z. B. Sars-CoV-2)

Kombi-Therapie für RNA-Virus-Erkrankungen mit Pyrimidin-Synthesehemmern und Nukleotidanaloga

Die COVID-19-Pandemie hat sich als die schwerste Gesundheitskrise der Neuzeit erwiesen. Zur Bekämpfung von RNA-Virusinfektionen wie SARS, Influenza, Hepatitis C, HIV und sogar Ebola wurde ein neuer kombinierter therapeutischer Ansatz aus Pyrimidin-Analoga und Pyrimidin-Biosynthese-Hemmern entwickelt.

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Antiviral combination therapy for RNA viruses (e. g. Sars)

Combination therapy for RNA virus diseases with pyrimidine synthesis inhibitors and nucleotide analogues

The COVID-19 pandemic has emerged as the most serious health crisis in modern times. To combat RNA viral infections like SARS, Influenza, Hepatitis C, HIV or even Ebola a new combination therapeutic approach of pyrimidine analogues and pyrimidine biosynthesis inhibitors has been discovered.

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Novel high current Channelrhodopsins

Improved Channelrhodopsins for future Optogenetic Therapies

By structure guided rational mutagenesis a superior Channelrhodopsin variant (ChReef) was developed from the Protein ChRmine. A desensitization effect could be reduced by a factor of three and at the same time the light induced photo-current of these variants is five times higher. This allows for an activation of neurons with lower light doses and/or a reduced expression level, which will reduce side effects.

 

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Pan-Coronavirus Therapy - viral genome disruption with Cas13

Pan-Coronavirus Therapy

Pan-Coronavirus Therapy using a Cas13-guideRNA system. The antiviral effect is based on an Cas13-guideRNA-AAV vector with up to five guideRNAs, which target and disrupt the genome of the Coronavirus - blocking viral replication. A therapeutic effect was proven in vivo in the SARS-CoV2 Hamster Model.

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GMP-compatible methods for tissue-engineered human heart tissue

GMP-compatible Methods for producing tissue-engineered human heart muscle from stem cells

Heart tissue engineering using stem cells is a recently developed technique to construct a three dimensional cell structure from cardiomyocytes or directly from progenitor cells. Scientists at the University of Göttingen developed two new and fully defined methods for serum-free production of engineered human heart muscles.

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Treatment of cardiac arrhythmia via re-expression of TBX5

Treatment of cardiac arrhythmia via re-expression of TBX5 (gene therapy)

Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy (TBX5 re-expression) for use in the prevention and acute treatment of a heart disease and associated complications (e.g. cardiac arrhythmia and sudden cardiac death).

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Pharmacologically controlled vector for CNS gene therapies

Regulatable CNS gene therapy reduces side effects

Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of a therapeutic factor (i.e. GDNF) with zero background expression, based on mifepristone (Mfp)-Gene Switch system, for the therapy of neurological diseases.

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Bio-engineered neuronal organoids from human stem cells

Bio-engineered neuronal organoids from human stem cells

Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production of human bio-engineered neuronal organoids (BENOs) from stem cells. This new method will allow for reproducible production of oganoids with fully functional neuronal network activity.

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Improved marker vaccine against classical swine fever

Improved marker vaccine against classical swine fever

Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses with improved DIVA (Differentiating Infected from Vaccinated Animals) properties. The used marker Erns is a chimeric sequence of two different and remotely related pestiviruses.

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1-vector otoferlin DFNB9 gene therapy

1-vector otoferlin DFNB9 gene therapy

Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded AAV virus mediated delivery into the cochlea. In vivo proof-of-concept successfully achieved.

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Targeted Demethylating Gene Therapy of Fibrosis

Targeted Demethylating Gene Therapy of Fibrosis

All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e. in heart, kidney, liver, lung, cancer). Normal re-expression of these genes has been achieved successfully in vitro and in vivo as well as a reduction of fibrosis.

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Prodrugs/drugs for a selective ADC tumor therapy

Prodrugs/drugs for a selective ADC tumor therapy

Scientists at the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-molar range) as well as a selective tumor therapy through their prodrugs. Selectivity is achieved by antibody tumor targeting. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site.

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